Glutathione-S-transferase activity in malarial parasites
نویسندگان
چکیده
منابع مشابه
Glutathione S-transferase activity and glutathione S-transferase mu expression in subjects with risk for colorectal cancer.
The glutathione S-transferases (alpha, mu, and pi), a family of Phase II detoxication enzymes, play a critical role in protecting the colon mucosa by catalyzing the conjugation of dietary carcinogens with glutathione. We investigated the efficacy of using the glutathione S-transferase (GST) activity of blood lymphocytes and GST-mu expression as biomarkers of risk for colorectal cancer. GST acti...
متن کاملAssociation between gastric mucosal glutathione-S-transferase activity, glutathione-S-transferase gene polymorphisms and Helicobacter pylori infection in gastric cancer.
AIM Helicobacter pylori infection, though common, leads to gastric cancer (GC) in less than 1% individuals, suggesting the role of host factors. We previously reported the role of glutathione-S-transferase (GST) polymorphisms, the gene encoding a carcinogen-detoxifying enzyme, in GC. This study was aimed to evaluate GST enzyme activity, GST polymorphism, glutathione (GSH) levels and H. pylori i...
متن کاملInduction of glutathione S-transferase activity in Triatoma infestans.
Several synthetic pesticides and allelochemicals used to treat Triatoma infestans adults by topic application showed some degree of cytosolic glutathione S-transferase (GST) induction. General inducers of detoxication systems such as phenobarbital and 3-methylcholantrene topically applied on T. infestans resulted in no GST induction. Meanwhile, general insecticide synergist such as piperonyl bu...
متن کاملGlutathione S Transferase Activity in the Basal Forebrain Cholinergic Population
The role of glutathione S transferase (GST) in the detoxification mechanisms in different organs is discussed in recent papers. In rat brain, where GST is located in the astrocytes/1-3/, the information concerning this topic is scarce. We present information about the levels of GST specific activity (GST-SA) in different rat brain areas and the effect of placental tissue homogenate (PTH), which...
متن کاملX-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum.
GSTs catalyze the conjugation of glutathione with a wide variety of hydrophobic compounds, generally resulting in nontoxic products that can be readily eliminated. In contrast to many other organisms, the malarial parasite Plasmodium falciparum possesses only one GST isoenzyme (PfGST). This GST is highly abundant in the parasite, its activity was found to be increased in chloroquine-resistant c...
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ژورنال
عنوان ژورنال: Tropical Medicine and International Health
سال: 1999
ISSN: 1360-2276,1365-3156
DOI: 10.1046/j.1365-3156.1999.00387.x